Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDC6 All Species: 10.3
Human Site: S13 Identified Species: 17.44
UniProt: Q99741 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.23
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99741 NP_001245.1 560 62720 S13 S Q A Q A T I S F P K R K L S
Chimpanzee Pan troglodytes XP_001170406 560 62717 S13 S Q A Q A T I S F P K R K L S
Rhesus Macaque Macaca mulatta XP_001096756 559 62520 S13 S Q A Q A T I S F P K K K L S
Dog Lupus familis XP_537648 559 62507 R13 S Q S Q A T I R F P K K K Q S
Cat Felis silvestris
Mouse Mus musculus O89033 562 62595 F14 Q T Q A T I G F P K K K L S N
Rat Rattus norvegicus NP_001101768 561 62295 F14 Q T Q A T I D F P K K K Q S K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519126 361 39672
Chicken Gallus gallus
Frog Xenopus laevis NP_001081844 554 60731 Q13 S R S Q S S I Q F P K K K T S
Zebra Danio Brachydanio rerio NP_001120805 561 61262 K33 P K S S C E N K V D D K T T P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648247 662 75116 S108 S T K K T V Q S A G S S R A K
Honey Bee Apis mellifera XP_625142 549 62089 K22 K C S F Y G N K H T V M K E D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_999666 582 64455 V16 Y F E E P L E V V K L F G L K
Poplar Tree Populus trichocarpa XP_002299817 498 55546
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P09119 513 58018 L16 T K R I R R N L F D D A P A T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 96 89.1 N.A. 79.5 80 N.A. 45.3 N.A. 63.7 49 N.A. 33.9 36 N.A. 40
Protein Similarity: 100 100 97.5 93.5 N.A. 87.3 88.9 N.A. 52.8 N.A. 77.5 67.3 N.A. 52.1 57.3 N.A. 58.5
P-Site Identity: 100 100 93.3 73.3 N.A. 6.6 6.6 N.A. 0 N.A. 53.3 0 N.A. 13.3 6.6 N.A. 6.6
P-Site Similarity: 100 100 100 86.6 N.A. 20 20 N.A. 0 N.A. 86.6 20 N.A. 26.6 13.3 N.A. 13.3
Percent
Protein Identity: 25.8 N.A. N.A. N.A. 20.1 N.A.
Protein Similarity: 46.4 N.A. N.A. N.A. 41.2 N.A.
P-Site Identity: 0 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 0 N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 22 15 29 0 0 0 8 0 0 8 0 15 0 % A
% Cys: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 8 0 0 15 15 0 0 0 8 % D
% Glu: 0 0 8 8 0 8 8 0 0 0 0 0 0 8 0 % E
% Phe: 0 8 0 8 0 0 0 15 43 0 0 8 0 0 0 % F
% Gly: 0 0 0 0 0 8 8 0 0 8 0 0 8 0 0 % G
% His: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 0 15 36 0 0 0 0 0 0 0 0 % I
% Lys: 8 15 8 8 0 0 0 15 0 22 50 43 43 0 22 % K
% Leu: 0 0 0 0 0 8 0 8 0 0 8 0 8 29 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % M
% Asn: 0 0 0 0 0 0 22 0 0 0 0 0 0 0 8 % N
% Pro: 8 0 0 0 8 0 0 0 15 36 0 0 8 0 8 % P
% Gln: 15 29 15 36 0 0 8 8 0 0 0 0 8 8 0 % Q
% Arg: 0 8 8 0 8 8 0 8 0 0 0 15 8 0 0 % R
% Ser: 43 0 29 8 8 8 0 29 0 0 8 8 0 15 36 % S
% Thr: 8 22 0 0 22 29 0 0 0 8 0 0 8 15 8 % T
% Val: 0 0 0 0 0 8 0 8 15 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _